The precise control of biochemical functions in eukaryotic cells relies on the spatial separation of metabolic pathways within membrane-bound organelles such as mitochondria, lysosomes, peroxisomes, and endoplasmic reticulum, which concentrate metabolic building blocks in optimal chemical environments. This metabolic compartmentation relies on dedicated specialized membrane-spanning transporters, direct physical connections for non-vesicular lipid transport, and localized signaling processes that harmonize organelle activities. Although metabolism has been extensively studied at the levels of whole cells and tissues, fundamental questions remain regarding metabolic regulation in organelles: how do cells maintain organellar metabolic homeostasis? Are there mechanisms to sense and respond to changes in compartmentalized metabolites?

This meeting will bring together scientists studying organellar metabolite compartmentation, its regulation, and the contribution to health and disease—from cancer to neurodegeneration.

Topics:

• Organellar metabolite maintenance
• Metabolite transporters
• Metabolic compartmentation in physiology and disease 
• Metabolic cooperativity