Keynote speaker

I am a biochemist and molecular physiologist whose research interests pertain to the structure and function of neurotransmitter receptors and ion channels, especially as this relates to mechanisms of sensory signaling. My group has been instrumental in identifying and/or characterizing ion channels that define specific subsets of primary afferent somatosensory nerve fibers; these include the capsaicin, menthol, and wasabi receptors (TRPV1, TRPM8, and TRPA1 respectively). We have exploited natural product pharmacology and mouse genetics, in combination with electrophysiological, anatomical, and behavioral assays, to elucidate cellular and physiological roles for these and other channels in nociception and itch under normal (acute) or pathophysiological (chronic) pain conditions. We also probe mechanisms of ion channel regulation using structure-function based approaches, ligand and toxin discovery efforts, biophysics, protein biochemistry, cryoEM and other structural and biophysical methods.

Mentorship is an essential and fulfilling aspect of my professional goals and career. I have been on the UCSF faculty for 34 years and trained a diverse and talented group of graduate students and postdoctoral fellows. Over 90% of Julius lab alums remain active in research and teaching, and many hold faculty or leadership positions at top-notch institutions in academia or industry. Beyond my own institution, I contribute to peer review, mentorship, leadership, and community outreach through service on editorial boards, grant review committees, advisory boards, and the like.

« Go Back