Speaker

Gerald S. Shadel earned a B.S. in Chemistry from the University of Nevada, Las Vegas in 1986 and received his Ph.D. in Biochemistry from Texas A&M University in 1991. Following this, Dr. Shadel was a Damon Runyon-Walter Winchell postdoctoral fellow in the Department of Developmental Biology at Stanford University. His initial faculty appointment was Assistant Professor of Biochemistry at Emory University from 1997-2003. In 2004, he joined the faculty at Yale School of Medicine, where he was a Professor in the departments of Pathology and Genetics, Director of the Yale Center for Research on Aging, and held the Joseph A. and Lucille K. Madri Chair of Experimental Pathology. He is currently a Professor at the Salk Institute for Biological Studies, the Audrey Geisel Chair of Biomedical Science and Director of the San Diego Nathan Shock Center of Excellence in the Basic Biology of Aging. Dr. Shadel’s research is directed toward understanding the mechanism of gene expression in human mitochondria and delineating signaling pathways that regulate mitochondrial function under normal physiological and pathological stress conditions. The ultimate goal is to gain a comprehensive understanding of how defects in these processes contribute to disease pathology that might in turn lead to novel therapeutic strategies. His major contributions include identifying and characterizing key factors and mechanisms that regulate expression and replication of yeast and mammalian mtDNA, defining mitochondrial stress-signaling pathways that maintain cellular homeostasis, and elucidating how mitochondria are involved in aging, disease and immunity. This has led to previously unappreciated roles for mitochondria in deafness, ataxia telangiectasia, innate and adaptive immune signaling, cancer and aging. His honors and awards include the “Amgen: Outstanding Investigator Award,” the “Breakthroughs in Gerontology” Award, the “Glenn Award” for Research on Biological Mechanisms of Aging, and Keynote Speaker at the 2015 FASEB meeting on “Mitochondrial Biogenesis and Dynamics in Health, Disease and Aging.”

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