Evans is Director of the Gene Expression Laboratory at the Salk Institute. He is known for pioneering studies on hormones’ normal activities and their roles in disease. A major discovery was nuclear hormone receptors, which respond to steroid hormones, vitamins A and D, thyroid hormones and bile acids. These receptors help control sugar, salt, calcium, cholesterol and fat metabolism, and are primary targets in breast, prostate and pancreatic cancers, leukemia treatment, and have therapeutic roles in chronic inflammation, osteoporosis and asthma. His muscle metabolism studies led to the discovery of exercise mimetics, which promote the benefits of fitness without training. Exercise mimetics will help battle the obesity epidemic, diabetes, heart disease, hypertension and cancer.
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